Drs. Germaine Escames and Dario Acuña are renowned experts in the field of melatonin and its clinical applications, with more than 25 years of research experience.
Germaine-Escames and Darío Acuña Professors Been studying the effects of melatonin at the cellular and mitochondrial level and Its clinical application for years, Which is Reflected in the large number of publications and projects Awarded on this subject. They have Studied the effects of melatonin and Its metabolites in different disease models : such as aging, Parkinson’s, Alzheimer’s, epilepsy, sepsis, fibromyalgia, Duchenne disease, as well as the application of melatonin in the adverse effects of Radio and chemotherapy and different inflammatory diseases . All published articles, books and book chapters, as well as various international and national communications to conferences, research projects, international collaborations, and dissemination events of the results Have Been Widely accepted in the scientific community. In turn, Acuna Castroviejo-Drs and Escames are members of the Editorial Board of the Journal of Pineal Research , one of the journals in the MOST prestigious area of physiology and are referee Numerous international scientific journals of high impact.
Globally, Drs. Acuña Castroviejo and Escames-are opinion leaders in the area of melatonin and Its clinical applications, and more than 200 international Have publications on the subject. Regularly Taught courses and conferences in Europe and USA and carry out intensive outreach on the subject of national media and foreign media.
The quality of Their publications Have led them to receive Several awards, Which are the Among Grant for Innovation in Research for characterising nocturnal melatonin ultradian rhythms in children; The Award for Excellence in Research by the University of Granada for demonstrating melatonin That Protects from oxidative stress mitochondria; The award for the best scientific publication for inducible nitric oxide synthase characterising in mitochondria and demonstrating ITS That melatonin counteracts effects; and the Sesvalia award for work on the Control of oxidative stress During rest.
Several They Also hold patents for the applications of melatonin, Such as one for ITS use in mucositis (an inflammatory process appears in the gastro-intestinal tract That During radio- and chemotherapy), another for an injectable formulation being used in a trial clinical melatonin to treat sepsis, and yet another for the use of melatonin on the skin.
Dr. Darío Acuña Castroviejo and Germaine-Escames Both Dr. Maintain collaborations With various universities including: the University of San Antonio (Texas, USA) through J Professor Russel Reiter, Whose laboratory They Regularly visit, and With the Neuroscience Institute at the University of Antioch (Colombia) through Professor Marlene Jimenez Where They are international research project Both advisors. They Also collaborate With Professor Daniel Cardinali at the University of Buenos Aires, an expert in melatonin, sleep, and neurodegenerative diseases: such as Alzheimer’s disease, as well various as Spanish universities (Valencia, Oviedo, Complutense University of Madrid, Zaragoza and Barcelona) .
Previous studies performed by our research group and funded by various projects, have allowed us to Demonstrate That mitochondria are a physiological and therapeutic target of melatonin and Its metabolites. We Have Demonstrated That Can Stimulate melatonin to Regulate the mitochondrial respiratory chain function and ATP production. , , Moreover, mitochondrial dysfunction counteracts Effectively melatonin in experimental models of various sepsis, aging, and Parkinson disease. Through Numerous research projects, We Have Demonstrated That melatonin can counteract the nigrostriatal damage induced by different Effectively neurotoxins, Including MPTP, as well as in mice in cultures of PC12 cells into dopaminergic NGF With Differentiated Neurons.Specifically, we Observed That Regulates melatonin levels in the striatum dopamine, Prevents dopamine autoxidation, normalisés complex I activity, ATP production, and substantia nigra in redox status in the mitochondria and nucleus of striate These mice. Likewise, melatonin synergises With selegiline (L-deprenyl) These mice recover while Their motility, and aids the recovery of tyrosine hydroxylase and dopamine activity levels.
We also found one of melatonin That’s metabolites, N1-acetyl-5-methoxykynuramine (AMK), Which is found in the brain, is more potent than melatonin itself in inhibiting neuronal nitric oxide synthase (nNOS) in the brain. In Addition, we Observed That mitochondria Actively capture melatonin and Its metabolites in a concentration and time-dependent manner, and to exert That These protective effect Within this organelle to Maintain ITS homeostasis. We showed melatonin That Protects the mitochondria present in tissues in irradiated rats tongue, THUS preventative mucositis. In a more recent project, we are using zebrafish as an experimental model of neurodegeneration, to Evaluate the effect of neuroprotective compounds (Extracted from microbes) on mitochondria and Their potential as therapeutic targets.That we have also shown.
These properties of melatonin (and Its metabolites) May be of great Importance in regulating Processes Which Depend on the modulation of mitochondrial bioenergetics. Recent studies Have Shown That the differentiation of neural stem cells is Accompanied by changes in mitochondrial mass, Both ATP and reactive oxygen species production, and the expression of antioxidant enzymes. THEREFORE, molecules can induce changes in mitochondrial function That Could play a role in the Best in Show regeneration of different tissues, the skin Including.