The prestigious journal AGE publishes a study on the prevention of pulmonary damage during aging, carried out at the University Of Granada

An increased lifespan is accompanied by a series of deficits that favour the appearance of age-associated diseases. These include an increased susceptibility to chronic respiratory diseases, such as emphysema, and acute ones, such as pneumonia, which are closely related to age and the increase in free radicals resulting from aging.

The results of our work, performed in SAM mice that undergo accelerated senescence, indicate that aging induces a hyper-oxidative state in lung mitochondria, and that this causes this increased susceptibility to respiratory diseases. Chronic treatment with melatonin, the main endogenous antioxidant in humans and mice (and whose production decreases with age), in these animals completely stopped the development of mitochondrial oxidative processes, and this was noted in their normal lung function.

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