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Professors Darío Acuña-Castroviejo and Germaine Escames have been studying the effects of melatonin at the cellular and mitochondrial levels and its clinical applications for years, and this is reflected in the many publications and project grants awarded to them to study this subject. They have studied the effects of melatonin and its metabolites in different disease models such as aging, Parkinson, Alzheimer’s and Duchenne diseases, epilepsy, sepsis, and fibromyalgia, as well as the application of melatonin in the combat of the adverse effects of radio and chemotherapy and in different inflammatory diseases. All of their published articles, books and book chapters, as well as their various communications at international and national conferences, research projects, international collaborations, and workshops designed to disseminate their results, have been widely accepted by the scientific community. In turn, doctors Acuña-Castroviejo and Escames are members of the editorial board of the Journal of Pineal Research, one of the most prestigious journals in the field of physiology, and are referees on numerous high-impact international scientific journals.

Doctors Acuña-Castroviejo and Escames are global-level opinion leaders in the area of melatonin and its clinical applications, and have published more than 200 international articles on the subject. They regularly teach courses and speak at conferences in Europe and the USA and carry out intense work to promote the subject in the national and foreign media.


Rodríguez MI, Escames G, López LC, López A, García JA, Ortiz F, Sánchez V, Romeu M, Acuña-Castroviejo D. Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone miceExptl Gerontol 2008;43:749-756. PMDI: 18485648.

Carretero M, Escames G, López LC, Venegas C, Dayoub JC, García L, Acuña-Castroviejo D. Long-term melatonin administration protects brain mitochondria from agingJ Pineal Res 2009; 47:192-200. PMDI: 19573039.

Acuña-Castroviejo D, Carretero M, Doerrier C, López LC, García Corzo L, Tresguerres JA, Escames G. Melatonin protects lung mitochondria from agingAge 2011; DOI 10.1007/s11357-011-9267-8. PMDI: 21614449.


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